We characterize early cancer development of the lung for which we use mouse transgenic cancer models. We which to characterize tissue niches during this development with a particular focus on the role of the tissue mechanical properties. For this purpose, we are applying spatial transcriptomics, primarily Stereo-seq, combined with snRNA-seq, and will integrate these data. These data will also be overlayed with microscopic images of the tissues carrying information of histology, tumor stages, and the organization of the extracellular matrix indicating the tissue stiffness. We will need computational resources for analysis and integration of all these data, containing very large data files typically 1-2 Tb each.