Understanding microbiome patterns in people living with HIV at baseline and after two years of SARS-CoV-2 vaccination
Dnr:
NAISS 2026/3-184
Type:
NAISS Medium
Principal Investigator:
Shilpa Ray
Affiliation:
Karolinska Institutet
Start Date:
2026-03-30
End Date:
2027-04-01
Primary Classification:
10203: Bioinformatics (Computational Biology) (Applications at 10610)
Secondary Classification:
10606: Microbiology (Medical aspects at 30109 and agricultural at 40302)
Allocation
- Cygnus /proj at UPPMAX: 5000 GiB
- Cygnus /proj/nobackup at UPPMAX: 5000 GiB
- Bianca at UPPMAX: 10 x 1000 core-h/month
Abstract
Our cohort includes 80 HIV patients and 80 Healthy controls, who were administered with SARS-CoV-2 vaccine and we had collected samples at baseline (before the vaccination) and two years later. We aim to analyze the metagenome data from these samples at baseline and after 2 years and group them according to their response to SARS-CoV-2 vaccine. We will divide these groups as high and low responders depending on the spike IgG titers and also aim to compare microbiome, metabolic pathways, and function at baseline and after two years.