In my PhD thesis, I will investigate the hybridization and migration of large mammalian species in North America using deep-time genomics – meaning with the use of genomes from individuals that lived during or before the Middle Pleistocene. I will do the following four thesis projects: 1) Quantify the extent of hybridization between the extinct stag moose and extant moose, 2) Investigate both the divergence of the extinct helmeted muskox from the extant tundra muskox and the tundra muskox’s migration into North America, 3) Examine the currently hypothesised timing of bidirectional horse migrations between Eurasia and North America and their impact on species diversity, and 4) Test the evolutionary relationships between Columbian, Woolly, and Krestovka mammoth lineages. This research will be groundbreaking and push the boundaries of aDNA sequencing and analysis. I will produce the first nuclear and mitochondrial genomes for stag moose and will also sequence some of the oldest mammoth and horse individuals from North America. My work will provide a better understanding of extinct and extant North American taxa that underwent large-scale climate change. My main supervisor is Dr. Love Dalén, Zoology Department, Stockholm University