What makes us move? Locomotion and its complex neural control in humans and animals have puzzled the scientific mind for centuries. Locomotory behaviour is partly regulated by circuits in the spinal cord, and injuries to this organ often result in a severe loss of movement and sensation and poses a great challenge for public health. However, some vertebrates are able to regenerate the spinal cord and restore locomotory function after injury. Among these species, the salamanders are the most robust regenerators, being able to restore a rich repertoire of walking and swimming locomotory patterns. Over the years, the cellular dynamics and the involved genes of spinal cord regeneration have been described in salamanders, but the regulatory mechanisms of gene expression that drive regeneration remain unclear. Recently, fast-evolving sequencing technologies have begun to characterise cis-regulatory elements in different regenerative systems. Against this background, this project aims to clarify the regulatory logic of spinal cord regeneration in salamanders with the hope of finding genetic switches for developing future therapies for spinal cord injury and advancing regenerative medicine.