Salmonid fish farming has been facing several challenges especially with diseases. Saprolegnia fungi infection is one of the greatest problems in salmonid hatcheries which causes losses from the egg incubation to the fish harvesting. Thus, saprolegnia disease consists of a huge problem in aquaculture industry and the development of methods to prevent or treat saprolegnia infection are necessary. In this regard, the use of gene editing technology by knocking out genes related to saprolegnia development, hypha formation, and adhesions proteins could be useful to highlight new targets for methods of prevention. Furthermore, the use of biological symbiosis or such as natural compounds produced by bacteria that inhibits fungi growth could also be an alternative especially in case of egg production as demonstrated in some species. The results obtained in this study will provide new information about saprolegnia for the development of new methods to prevent saprolegnia disease and improve salmonid fish farming.