Psoriasis is a common inflammatory disease with highly variable outcomes among individuals. Some patients develop psoriatic arthritis (PsA), others recover fully, while some experience chronic inflammation and related comorbidities. In this project, we will analyze whole genome sequencing (WGS) data (654 patients, 192 controls; total raw data size ~35 TB), generated in collaboration with the NIH and linked to the Stockholm Psoriasis Cohort, to identify genetic variants associated with these diverse clinical outcomes.