Severe burns is a very serious medical condition associated with high mortality, morbidity, personal suffering and high societal costs. Severe burns require multiple surgeries in order to heal and triggers a strong inflammatory overreaction, which in itself can lead to organ failure and death. Long-term intensive care is often needed to support the patient during healing. It is not known how patient or injury factors affect this process. There are indications that the inflammatory overreaction persists for many years after the initial injuries have healed, and previous studies have indicated that burn victims have increased risk of death many years after the injury. It is therefore of great importance to find ways to prevent burn injury, optimise burn care and improve care after burns. This project is a large register linkage, collecting information from the Swedish National Patient Register, the Swedish Intensive Care Unit Registry, the National Cause of Death Register, the National Prescribed Drug Register, and the Longitudinal Integrated Database for Health Insurance and Labour Market Studies (LISA) for all individuals having suffered a burn injury 1987-2023. For each burn patient, four comparison individuals are drawn from the Register of the Total Population, matched for sex, age and geographical region. The aim of this project is threefold: first, to explore risk factors associated with sustaining a burn injury, including socioeconomic factors, somatic and psychiatric comorbidities and prescribed drugs, in order to direct preventative measures towards individuals with the highest risk. Second, to investigate the intensive care and surgery of severe burns, in order to find patient or injury factors affecting the clinical course or outcome; improve risk stratification; chart the need for organ supportive treatment; find the prevalence of complications and find risk factors for complications; and to examine potential trends in outcome over time or between geographic reagions. Third, to examine life after burns in the long term, including the risk of death; risk of developing new medical conditions due to the inflammatory reaction, such as cancer, cardiovascular disease or diabetes; mental health, abuse and use of psychiatric medication; long-term pain and use of pain medication; and socioeconomic trajectory after injury, in order to guide follow-up of burn patients. In summary, severe burns is a serious medical condition associated with high mortality and morbidity. This project is a large registry linkage including all individuals having suffered a burn injury 1987-2023 and matched comparison individuals from the Swedish population aiming to investigate risk factors for sustaining a burn injury, the intensive and surgical care and the long-term outcome of burns. Results may help preventive efforts, optimise initial care and aid in follow-up of burn patients.