Heat waves represent a significant threat to global agriculture, underscoring the urgent need for efficient and targeted crop protection methods. This project confronts that urgency by building on our recent discovery that plants initiate a rapid heat stress response through the dynamic modulation of protein networks, specifically via biomolecular condensates. Expanding on insights gained from our ERC Consolidator Grant project (“PLANTEX”), we identified that SEC14-like proteins—especially the plasma membrane-associated SFH8—undergo a phase transition from liquid-like to solid-like condensates. This transformation governs the translation of stress-responsive proteins, ultimately influencing plant growth. SFH8 contains numerous intrinsically disordered regions (IDRs), which exist as a variety of rapidly shifting configurations that are computationally challenging and expensive to model. We aim to probe the conformational landscape of SFH8. With allocated computational resources, we will simulate SFH8 configurational transitions at an atomic level under different salt conditions—achieving insights that experimental techniques alone cannot provide. Our goal is to decode the mechanisms behind SFH8’s structural ensemble and its tendency to multimerize. Computational findings will be validated alongside experimental approaches, generating mutation targets for future crop resilience efforts. Moreover, given the broader biological relevance of SEC14 proteins in human systems, the project holds promise for advancing both agricultural sustainability and medical research.