The malaria causing agent, Plasmodium falciparum, inflicts the highest rate of morbidity and mortality among all the vector-borne diseases, with an estimated 224 million infections and 620,000 deaths per year. The current paradigm for malaria intervention calls for strategies to hamper transmission between the mosquito vector and the human host. My team at Stockholm University implements novel single-cell and spatial omics tools in combination with computational applications developed “in house”, in order to improve our understanding of the biology linked to transmission. To this end we generate large amounts of single cell, spatial and imaging data to study the interplay between the parasite and the host tissues, as well as data from the mosquito vector.