The aim of this project is to integrate genome and metabolome data to identify the mQTL loci. In previous studies, we have identified a large number of genetic variants affecting the concentration of blood metabolites (called mQTLs) in S3WP cohort. In this study we will extend our research in different large-scale cohorts such as UK Biobank, SCAPIS, CLSA etc. A meta-analysis will then used to integrate all the studies to establish a comprehensive genetic atlas of the human metabolome.