Aortic valve stenosis (AVS) is a leading cardiovascular disease that causes a progressive narrowing of the aortic valve as a consequence of thickening and calcification. Emerging evidence shows that lipid deposition and the unbalance between pro-inflammatory and inflammation-resolving determine the disease progression. Valvular interstitial cells (VICs), the primary cellular component of the heart valve, have been revealed undergoing phenotype transition during CAVD progression. Moreover, as a lipids-driven chronic inflammatory disease, AVS is also facilitated by the involvement of immune cells. Recently, the pathobiology of AVS has become better understood due to the development of advancing single cell sequencing techniques. However, the effect of lipid oxidation and inflammation-resolving on AVS have not yet been deeply investigated. The aim of this project is to establish a comprehensive database that includes published single-cell data, our own single-cell data, and the single-cell sequencing data from other human samples in the context of AVS. This database will not only map the human aortic valve cell atlas but also offer insights into the complex cytopathological differentiation processes involved.