“The importance of the intrauterine environment for gene expression, epigenetic markers and later metabolic morbidity”
Dnr:
sens2025010
Type:
NAISS SENS
Principal Investigator:
Fredrik Ahlsson
Affiliation:
Uppsala universitet
Start Date:
2025-03-14
End Date:
2026-04-01
Primary Classification:
30221: Pediatrics
Webpage:
Allocation
- Cygnus /proj/nobackup at UPPMAX: 300 GiB
- Cygnus /proj at UPPMAX: 300 GiB
- Bianca at UPPMAX: 1 x 1000 core-h/month
Abstract
The objective of this project is to ascertain alterations in umbilical cord DNA methylation in children born large for gestational age (LGA) in comparison to children born appropriate for gestational age (AGA). The hypothesis is that altered growth in utero is due to fetal programming through DNA methylation, and that this results in heavier birth weight, altered body composition, metabolism, and risk of altered growth pattern later in childhood.