The overall purpose of the project is to systematically investigate the mechanistic role of psychosocial factors (such as perceived stress, social isolation, and socioeconomic status) and sleep on the risk of metabolic disorders, cardiovascular diseases (CVDs), and cancer using a multidisciplinary approach, including traditional and molecular epidemiology. We will investigate the link between self-reported and register-based information on psychosocial and sleep-related factors and the risk of metabolic disorders, cancer, and CVDs in total and stratified by socioeconomic status (SES) or by health status. The outcomes of interest include metabolic disorders (e.g., type 2 diabetes, metabolic syndrome, and its components), CVDs including heart failure, myocardial infarction, coronary heart disease, atrial fibrillation, aortic valve stenosis, stroke and stroke types, abdominal aortic aneurysm, and overall and CVD mortality, as well as site-specific cancers (e.g., breast and prostate cancers). In addition, we want to identify circulating proteins and metabolites associated with e.g., poor sleep, stress, social isolation, SES, and disease outcomes to better understand the underlying molecular mechanisms linking these modifiable factors and the risk of specific CVDs, cancer, and metabolic disorders. Finally, we aim to investigate if identified psychosocial and sleep-related risk factors or related biomarkers may improve the prediction of specific disease outcomes in addition to traditional cardiovascular risk factors.