Prostate cancer patients with a family history of at least one other close relative with the same disease are considered high-risk or familial prostate cancer. Today variants in the gene BRCA2 and the DNA mismatch repair genes are known to be associated with increased risk of prostate cancer. This project will use WGS to search for variants in these patients and the project will use available knowledge from GnomAD for comparison of frequencies of variants in these high-risk prostate cancer cases.