Background: The chronic inflammation behind atherosclerotic CVD (ASCVD) and its cardiovascular consequences are largely caused by a failure in the resolution of inflammation. Elevated levels of blood lipids (hyperlipidemia) are well documented risk factors for cardiovascular health-to-disease transition by triggering the chronic inflammation. Hypothesis: While lipid-lowering is an effective way to reduce the ASCVD risk, the residual risk remains high mainly due to chronic inflammation. Since the lipid dimension also comprises inflammation regulation, an appropriate lipid intake as dietary intervention complementary to already proposed ones for ASCVD can pave ways towards inflammation resolution and development of global prevention strategies. Method: In the proposed CArdiovascular REsolution of INflammation to promote HEALTH (CARE-IN-HEALTH) project, we collect clinical characteristics, genetic variations, PUFA exposure by dietary intake, and biomarkers, available in SIMPLER cohorts. Data analyses will use epidemiological approaches as well as creating advanced machine learning models for a resolving and non-resolving inflammation to predict the health-to-CVD transition. The CARE-IN-HEALTH project will perform replication studies across outcomes and cohorts through the ongoing analysis in the SCAPIS and STANISLAS, meaning that available cardiovascular phenotyping, genetics, and proteomics from two additional cohorts will be analyzed to test our major hypotheses. Aim: The overarching objective of this project is to overcome the unmet medical need of detecting and monitoring CVD risk markers of chronic inflammation and to identify the resolution of the chronic lipid-driven/-regulated vascular inflammation in order to develop and test health-care tools for citizens to stay healthy by an adequate resolution of chronic inflammation.