The molecular clock is a fundamental biological mechanism that regulates various rhythmic physiological processes in mammals, including the sleep-wake cycle and metabolism. In this context, gene expression and metabolites from tissues taken from mice that have had the clock disrupted, can provide valuable insights into how the molecular clock regulates metabolism in a tissue-specific manner. In this study, we are analyzing tissue samples from mice that have had the clock disrupted, and have been exposed to different diets. Specifically, tissues such as liver, muscle, and adipose tissue have been collected and have undergone analysis for changes at the gene to metabolite level. The data generated from this study could then be used to identify clock-controlled pathways or networks that are involved in the regulation of 24-h metabolism. This may aid the development of interventions aimed at optimizing the regulation of the molecular clock and improving overall health and well-being.