SUPR
PNS/CNS Cellular identity in primates and rodents
Dnr:

NAISS 2024/22-1214

Type:

NAISS Small Compute

Principal Investigator:

Patrik Ernfors

Affiliation:

Karolinska Institutet

Start Date:

2024-10-01

End Date:

2025-10-01

Primary Classification:

30105: Neurosciences

Webpage:

Allocation

Abstract

Sensory neurons of dorsal root ganglia (DRGs) sense and conduct to CNS different sensory modalities (heat, cold, itch, mechanosensation, pain) from body surface and viscera. The primary sensory system requires the integrated function of multiple cell types, although its full complexity remains unclear. Recently we presented comprehensive transcriptome analysis of several hundred single DRG neurons from mouse and classify them in an unbiased manner. In current project we sequence transcriptome of individual sensory neurons from macaques in order to determine sensory neurons populations existing in this species Continuations of projects b2016178 and g2017018.