Potential genomic effect of serial cycling of Borrelia strains in sublethal levels of human complement
Dnr:
NAISS 2024/23-519
Type:
NAISS Small Storage
Principal Investigator:
Tobias Jakobsson
Affiliation:
Umeå universitet
Start Date:
2024-09-20
End Date:
2025-10-01
Primary Classification:
30108: Cell and Molecular Biology
Webpage:
Allocation
Abstract
The two Borrelia garinii strains ZQ1 and G1 have been serial cycled in vitro in sublethal levels of human serum to see if this can induce genetic changes. The strains have been whole genome sequenced at low, medium and high passage using Illumina and PacBio to see if and when genetic changes occur.