Compared to resistance breeding and chemical pesticides, the use of plant resistance inducers (PRIs) have appealing aspects in agriculture. For example, by activating the plant’s own defence, PRIs work indirectly on pathogens via the plant not affecting “off-target” organisms. Moreover, PRI-triggered responses are usually complex, lessening the risk of resistance development in pathogen populations compared to resistance by single genes introduced by breeding. To address set of questions about PRIs, we use pathosystems we have extensive experience of, namely crops potato and tomato and pathogens Alternaria solani and Phytophthora infestans, which have great economic impact in agriculture. We want to 1) explore PRIs role in nutrient composition, immunity and fitness of plants by advanced phenotyping coupled to metabolite and enzymatic analyses, 2) test how PRIs will perform in future climates with increased CO , 3) screen for inducibility of resistance by PRIs in unique diploid potato lines, and 4) see if cyanobacteria can be a source of organic phosphite, a promising PRI, and test its degradation in tropical soils. Answers to these questions will give insight to the role of PRIs in production of nutritious and resource-efficient food, whether climate change can affect PRI efficiency and the chance to include resistance inducibility in future breeding programs. This paves the way for broader adaption of PRIs in cultivation and as part of Integrated Pest Management.