Cancer is the second most prevalent cause of death worldwide despite constant efforts towards biomarker discovery and therapeutic development. A plethora of studies have identified differentially expressed molecules as biomarkers for all types of cancer. However, in many cases, biomarker detection requires accurate quantification that is not always possible due to technical limitations or that is only measurable at late stages. At the same time, the mechanisms that drive cancer in relation to its different hallmarks are not completely understood. Here, we aim to discover small RNA molecules are only present in cancer tissues and completely absent from healthy ones. These molecules may not only be excellent biomarkers due to their specificity to cancer tissues but also help us understand some of the molecular processes involved in cancer. To this end, we intend to analyze publicly available datasets of various cancer types for candidate molecules, validate them and determine their functionality. Our goal is to provide a list of small RNA molecules that are specific to cancer and can be used as biomarkers. We envision that this list can be a powerful resource for cancer researchers and clinicians all over the world and could assist the fight against cancer.