SUPR
Proteogenomics clinical samples
Dnr:

sens2024567

Type:

NAISS SENS

Principal Investigator:

Janne Lehtiƶ

Affiliation:

Karolinska Institutet

Start Date:

2024-05-31

End Date:

2025-06-01

Primary Classification:

10610: Bioinformatics and Systems Biology (methods development to be 10203)

Allocation

Abstract

Neoantigens provide a promising source for targeting cancer cells through targeted re-activation of immune cells. However, identifying neoantigens is a challenging task due to their low abundance and cancer heterogeneity. We have developed a proteogenomics pipeline which takes processed sequencing (RNA, DNA) data and proteomics data from matching human clinical samples as inputs, and uses the sequences to find unconventional mutant peptides in the proteomics data. Prior to running this pipeline on normal infrastructure, sequencing data must be processed in order to create sequences of non-sensitive somatic cancer mutations. This part we aim to run on Bianca.