My team at Uppsala University has collaborated with a large set of experts from around the world to collect, sequence, and generate novel genome assemblies for ~150 Eutherian mammal species. These genomes have now been aligned together with the ~50 mammalian genomes available prior to this study to generate a dataset that has allowed the detection of mammalian constraint at single base pair resolution. After publishing 11 papers in Science in April 2023 we are now using this data to study genome evolution, signs of positive selection and identification of mutations related to disease. We plan to perform extensive analyses on this alignment to understand the role of functional constraint and divergent evolution on genome regulation