SUPR
Genome regulation
Dnr:

NAISS 2024/6-80

Type:

NAISS Medium Storage

Principal Investigator:

Pelin Sahlén

Affiliation:

Kungliga Tekniska högskolan

Start Date:

2024-05-08

End Date:

2025-05-01

Primary Classification:

10203: Bioinformatics (Computational Biology) (applications to be 10610)

Secondary Classification:

10610: Bioinformatics and Systems Biology (methods development to be 10203)

Allocation

Abstract

This storage project will keep the fastq files of non-sensitive data Sahlen Lab produced for multiple projects. Sahlen Lab investigates the role of non-coding genome in health, disease and evolution. We use targeted chromosome capture (HiCap) method developed in our lab to produce high-resolution promoter-enhancer interactions. Only the fastq files of the projects that we are actively working on will be stored here. The fastq files of the completed projects will not be stored here and will be backed up on at least two physical drives. The experiments contains whole-genome sequencing, transcriptome sequencing, chromatin immunoprecipitation and targeted chromosome conformation capture experiments. There are currently three active project that we are working on 1. the role of enhancers in canine evolution: we have experimental data from seven tissues of 16 animals. : 10 TB 2. metainteractome project: the transcriptome and interactome data of 30 different cell lines to characterise cell-specific enhancer usage. : 12 TB 3. Functional characterisation of non-coding genes (lincRNAs): our lab is part of the FANTOM6 consortium and we will work with DNA-RNA interaction data from seven different cell lines. : 22 TB