SUPR
Spatial transcriptomics data analysis of immune infiltration in bladder cancer
Dnr:

NAISS 2024/23-271

Type:

NAISS Small Storage

Principal Investigator:

Viktor Sincic

Affiliation:

Lunds universitet

Start Date:

2024-05-06

End Date:

2025-06-01

Primary Classification:

30110: Immunology in the medical area

Webpage:

Allocation

Abstract

Immunotherapy has revolutionized the way cancer is being treated and provided the possibility of dramatically increased survival for cancer patients. However, only about 20% of patients respond to this treatment and additional therapeutic interventions are urgently needed to increase this number. To develop new immunotherapies, a better understanding of the tumor immune microenvironment is needed. This project seeks to investigate the immune infiltration in bladder cancer tumors using spatial transcriptomics. The goal is to better understand how tumor cells and different immune cells interact with each other and how these interactions could be manipulated to generate a more potent anti-tumor response. We have generated spatial transcriptomics data of bladder tumors using the Xenium platform and to analyse this large and complex data we need additional computing power.