Transcriptional profiling of neuronal cells and reprogramming process
Dnr:
NAISS 2024/22-489
Type:
NAISS Small Compute
Principal Investigator:
Masahito Yoshihara
Affiliation:
Karolinska Institutet
Start Date:
2024-05-01
End Date:
2025-05-01
Primary Classification:
10610: Bioinformatics and Systems Biology (methods development to be 10203)
Webpage:
Allocation
- Klemming at PDC: 500 GiB
- Crex 1 at UPPMAX: 128 GiB
- Dardel at PDC: 2 x 1000 core-h/month
- Rackham at UPPMAX: 2 x 1000 core-h/month
Abstract
We will investigate the transcriptional and chromatin formation changes of neuronal cells during the differentiation and drug response. In addition, we will attempt to elucidate the mechanism of the reprogramming process using the human early embryonic cell model by transcriptome profiling.