Nodal diffusion codes, that are used in industry for reactor simulations require spatially homogenised and energy collapsed nodal data, such as group macroscopic cross sections, microscopic cross sections for selected nuclides, diffusion coefficients, discontinuity factors, etc. The nodal data depends on both instantaneous and historic state variables, such as fuel depletion, fuel temperature, moderator density, and others. Nodal data generation is carried out by computationally expensive neutron transport codes, and it is impractical to generate nodal data on demand from these codes, therefore, it is necessary to build simplified models of the nodal data based on its state dependencies. These dependences are usually tabulated or approximated by multivariate functions (Dufek 2011), mostly polynomials. The general problem with the table models is that tables grow exponentially with the number of state variables. The amount of data stored in the tables and the number of lattice calculations needed to fill the tables can easily become impractically large for this reason. Therefore, the table models can consider only relatively few state variables. In this PhD project, we propose the application of Artificial Neural Networks (ANNs) to represent nodal data. The advantage of Artificial Neural Networks is its capacity to represent highly complex and non-smooth functions, which we believe may lead to more accurate nodal data representation compared to the models in the current literature. This would allow for more flexible and accurate reactor simulations than possible with existing data models. This can translate into a better optimisation of fuel load patterns and an improved reactor economy.