The development of of nociceptors or pain sensing neurons requires a transcription factor called Prdm12 in mice. In addition, our lab demonstrated that Prdm12 requires co-factors to operate. However, these co-factors are not yet elucidated, and the target motif of Prdm12 is still unclear. We also believe that Prdm12 plays a critical role during pain chronification. Thus, we aim to address these problems through single-cell multiomics approach such as ATAC-, Cut&Tag-, and RNA-sequencing. The analysis of the dataset would be also helpful in constructing the gene regulatory network model of pain and pain associated disease, and could potentially reveal therapeutic targets of the diseases.