SUPR
Palaeogenomic investigation of human phenotypes and fine-scale population dynamics in Anatolia: During, before and beyond the Bronze Age
Dnr:

NAISS 2024/22-392

Type:

NAISS Small Compute

Principal Investigator:

Ricardo Rodríguez Varela

Affiliation:

Stockholms universitet

Start Date:

2024-04-01

End Date:

2025-04-01

Primary Classification:

60103: Archaeology

Webpage:

Allocation

Abstract

This study focuses on the beginning of Bronze Age in North Anatolia and expands its time frame backward and forward in time with the purpose of understanding dynamics of allelic architecture associated with a set of human diseases and phenotypes. Here, we aim to understand (i) fine-scale human population dynamics in North Anatolia, at the beginning of the Bronze Age i.e. origins of the locals and migrants, and to discover (ii) how genetic architecture associated with a set of complex diseases and phenotypes have changed during, before and after early Bronze Age in North Anatolia. We will analyse a multi-dimensional data which includes multiple data sources i.e. shotgun sequencing data, in-solution hybridization enrichment data, and isotope (Sr and Ox) data. We will prepare genomic datasets and perform population genetics analysis such as PCA, ADMIXTURE, f-statistics, qpAdm. We will also compute allele frequency trajectories over time for the SNPs that we generated capture data.