The effect of intestinal fluid composition on self-assembly and drug solubility in lipid based formulations.

NAISS 2024/5-115


NAISS Medium Compute

Principal Investigator:

Per Larsson


Uppsala universitet

Start Date:


End Date:


Primary Classification:

30101: Pharmaceutical Sciences

Secondary Classification:

30103: Medicinal Chemistry



Oral administration of drugs requires sufficient solubility of the active ingredient in gastric or intestinal fluid to allow complete absorption. Modern drug discovery techniques often generate lead compounds with low aqueous solubility. This translates to an inefficient and expensive drug development process since time and resources are spent on drug candidates that in the end cannot easily be administered in vivo. This study aims to increase the understanding of the molecular basis in the solubilization of poorly soluble compounds in physiological fluids containing lipids. If the mechanisms behind the solubilization in these lipid aggregates could be understood on a molecular level, knowledge-driven decisions about solubility-related issues could be made much earlier during the drug development process. In the continued project, we want to expand our studies to include how differences in pH, etc affect drug aggregation and absorption propensities. We also want to explore around different drug dosage forms, such as amorphous solid dispersions, and how those are affected by intestinal fluid components.