Severe psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BIP) and anorexia nervosa (AN), are frequently comorbid with lung function decline and asthma. Despite their considerable heritability, the genetic relationships between them are inconclusive. We will thoroughly investigate the shared genetic architecture between three severe psychiatric disorders (SCZ, BIP and AN) and lung function (forced expiratory volume/forced vital capacity ratio) and asthma based on available genome-wide association studies. We will perform linkage disequilibrium score regression analyses (LDSC) and MiXeR to quantify their genetic overlap. A conditional/conjunctional FDR (cond/conjFDR) approach will be employed to identify shared genomic loci. Functional annotations, gene mapping and gene-based enrichment analyses will be adopted to explore the shared biological mechanisms. Transcriptome analyses will be conducted to identify shared genes across different tissues. Whether you won't need more time than that or your plan to move to another system before the end of the year: I am sure I will only need Rackham for this project before the end of 2024. Most of the analyses for this project were already completed on other servers. I will only use the rackham server to test the parameters of cond/conjFDR analyes as a validation of my current results (my project affiliated to other servers were allocated a limited CPUs and time combination). The completion of cond/conjFDR analyses for each pair of phenotypes will require 16 cores for 3 days. However, if the analyses can be performed in parallel for multiple pairs of phenotypes, the total time required for 6 pairs of phenotypes in the current study will be substantially shortened. Furthermore, I have already established a feasible pipeline to perform the cond/conjFDR analyses so I don’t need to spend extra time in testing the script. This project is one of the four obligatory studies for my PhD so it is expected to be finished this summer.