This project explores scenarios for federated analysis of genomic variations in patients to assist in profiling them for treatment and to support research in rare diseases. A use case will be used to identify requirements on interfaces between a virtual platform and the connected resources, on the data objects that are communicated, and the services that process the data. Some focus will be on leveraging solutions offered by B1MG/GDI compatible resources that enable secure and federated queries for genomic/phenotypic information. The compute resources will be used to process synthetic data to produce relevant examples and test data for the virtual platform implementation.