SUPR
Translational check for novel mast cell populations within a scRNA data-set of human airways with asthma
Dnr:

sens2024524

Type:

NAISS SENS

Principal Investigator:

Jenny Hallgren Martinsson

Affiliation:

Uppsala universitet

Start Date:

2024-02-29

End Date:

2025-03-01

Primary Classification:

30110: Immunology in the medical area

Allocation

Abstract

In our preliminary manuscript we have identified novel mast cell populations in the lung of mice with house dust mite-induced allergic airway inflammation identified by single cell CITEseq analysis. Our aim now is to use the EGA single cell data to determine whether we can findsimilar human mast cell populations in airway samples from patients with allergic asthma (and perhaps not in the healthy controls). If so, that would be really nice to include in our manuscript as a translational part.