SUPR
Southern Africa resequencing
Dnr:

NAISS 2024/22-173

Type:

NAISS Small Compute

Principal Investigator:

Nikola Vukovic

Affiliation:

Uppsala universitet

Start Date:

2024-03-01

End Date:

2025-01-01

Primary Classification:

10615: Evolutionary Biology

Webpage:

Allocation

Abstract

It is well known that Africa harbours the highest level of genetic variation among all humans. Yet, african populations, especially indigenous ones, remain largely understudied. In this study we aim to analyze the genetic makeup of seven southern African populations, with different social, cultural and linguistic backgrounds. Having access to high quality, whole genome data, we have the opportunity to employ a wide array of population genomics analyses such as ADMIXTURE, PCAs, Relate, conduct selection & demographic modelling, run coalescent simulations (msprime), ABC-RF, as well as estimate divergence times (TT test/TTo). By deconstructing the genomes of these individuals into Khoe-San and non Khoe-San segments, we hope to disentangle the multiple waves of population migration and obtain a deeper understanding of the rich & complex evolutionary history of this part of the African continent.