SUPR
Genetic analysis of ethnic groups with differential susceptability to p.falciparum
Dnr:

NAISS 2024/22-92

Type:

NAISS Small Compute

Principal Investigator:

Mareike Polenkowski

Affiliation:

Stockholms universitet

Start Date:

2024-01-26

End Date:

2025-02-01

Primary Classification:

10602: Biochemistry and Molecular Biology

Allocation

Abstract

The immune system is always complex and includes many different immune cell types, and molecules which function together to fight against the infection. The outcome of these interactions varies between individuals and populations depending on genetic and environmental factors. Here in this project, we are exploring how genetically different ethnic groups respond toward the malarial parasite, Plasmodium falciparum. Several studies showed that Fulani shows more resistance toward P.falciparum. Here we are investigating the role of genetics and epigenetic determinants involved in this immune response.