Oligodendrocytes (OL) are glial cells that mediate myelination of neurons. During OL precursor cells (OPC) proliferation the interplay between transcription factors and epigenetic modifiers is essential for the acquisition of specific cell fates. The disruption of these states can decrease the ability to repair myelin in Multiple Sclerosis (MS). In our group we are interested in deciphering the oligodendrocyte states using single cells omics, from transcriptiomics to epigenomics and more recently combining with spatial single cell omics. We will continue to use it for analyzing single cell sequencing data from oligodendrocytes in mouse tissue from homeostatic states and disease, to understand the transcriptome and the epigenome of oligodendroglia.