Pharmacometric modelling of biomarker and organ responses in sepsis
Dnr:
NAISS 2023/22-1325
Type:
NAISS Small Compute
Principal Investigator:
Salma Bahnasawy
Affiliation:
Uppsala universitet
Start Date:
2024-01-01
End Date:
2025-01-01
Primary Classification:
30101: Pharmaceutical Sciences
Webpage:
Allocation
- Klemming at PDC: 500 GiB
- Crex 1 at UPPMAX: 128 GiB
- Dardel at PDC: 2 x 1000 core-h/month
- Rackham at UPPMAX: 2 x 1000 core-h/month
Abstract
The overall aim of this project is to use pharmacometric models to quantitatively characterize the process of bacterial sepsis induction, and to evaluate how the pathophysiology of sepsis affects the pharmacokinetics and optimal dosing of antibiotics in patients with sepsis.