Development of novel types of aggregates to help with the understanding of neurodegenerative diseases
Dnr:
NAISS 2023/22-1242
Type:
NAISS Small Compute
Principal Investigator:
Greta Hultqvist
Affiliation:
Uppsala universitet
Start Date:
2023-12-07
End Date:
2025-01-01
Primary Classification:
30105: Neurosciences
Allocation
- Dardel-GPU at PDC: 200 GPU-h/month
- Crex 1 at UPPMAX: 128 GiB
- Rackham at UPPMAX: 2 x 1000 core-h/month
Abstract
In neurodegenerative diseases, aggregates of proteins, causes nerve cells to die. How this aggregation happens and how the toxicisty happens is not fully understood. We will here use Alpha fold to study the folding of these aggregates to learn more about the aggregation process. After we have studied them in with alpha fold, we produce these constructs and study them in vitro.