Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer with currently no efficient drug treatments. Our lab aims at understanding the interactions between tumour cells and the surrounding microenvironment. A molecular and functional characterization of the interactions with surrounding stroma might identify novel therapeutic targets. In this project, stroma and cancer cells from a mouse model of PDAC will be characterized using RNA-sequencing and chromatin (ATAC-seq) profiling.