The Clinical Genetics group at the Karolinska Institutet is studying chronic lymphocytic leukemia (CLL), trying to better understand the disease, its progression, subtypes, and molecular biology explaining differences in treatment response. As part of this effort, we are in the process of generating a large cohort of patients from across Sweden, involving targeted DNA panel sequencing and RNA sequencing to start with. These large datasets will thus include multiple assays from around 500 patients. We are therefore applying for a project on Bianca, to serve as the main computing resource to jointly analyze these datasets. Several people are involved in this study, including PhD students, postdocs, and bioinformaticians. This will be a new valuable and big source of information to further our understanding of CLL, and the infrastructure from Bianca would help us in this effort by providing the computing resources that are needed to analyze such a large cohort.