MESARGEN is an international framework created by Natalia Rivera (Principal Investigator). MESARGEN aims to conduct genetic investigations using large sample sizes, including diverse ethnic populations with well-phenotyped clinical data and molecular phenotypes. Using high-throughput sequencing and SNP-array technologies coupled with cutting-edge bioinformatics and statistical methods, we intend to elucidate the underlying genetic architecture of sarcoidosis and target-organ phenotypes (pulmonary, cardiac, skin, ocular, and neurosarcoidosis) as well as other extrapulmonary manifestations. We aim to map genetic variation of sarcoidosis signals across populations and ethnic groups worldwide.