The Human Protein Atlas (HPA) is a Swedish-based program initiated in 2003
with the aim to map all the human proteins in cells, tissues, and organs using an
integration of various omics technologies, including antibody-based imaging,
mass spectrometry-based proteomics, transcriptomics, and systems biology. All
the data in the knowledge resource is open access to allow scientists both in
academia and industry to freely access the data for exploration of the human
proteome. The open access web resource is used by over 200 000 researchers
The Human Protein Atlas consortium is mainly funded by the Knut and Alice
Currently HPA consists of 12 sections - this specific project relates to the
Structure section. The Structure section contains information about the three-
dimensional structure of human proteins. The predicted 3D structure from the
AlphaFold Protein Structure Database project is shown together with
experimentally determined structures from the Protein Data Bank (PDB).
Today we have imported structure predictions directly from AlphaFold which are
based on the canonical Uniprot sequence, since HPA is based on the reference
protein coding genes from Ensembl this gives rise to an incomplete dataset and
In this project we will run the AlphaFold protein structure prediction software for
all proteins listed in HPA (n=86500). One of the main improvements of running
these predictions on the same sequence base as HPA uses is that we can
integrate all other sequence features from HPA into the predicted 3d-structures.
The results will be published in Human Protein Atlas version 24, released autumn 2024.