SUPR
Detecting selection through structural variants
Dnr:

NAISS 2023/22-1111

Type:

NAISS Small Compute

Principal Investigator:

Marianne Dehasque

Affiliation:

Uppsala universitet

Start Date:

2023-10-26

End Date:

2024-11-01

Primary Classification:

10609: Genetics (medical to be 30107 and agricultural to be 40402)

Webpage:

Allocation

Abstract

Structural variants are an important source of adaptive traits. Yet, this type of variation has remained largely unexplored in wild populations. In this project, we will study selection through structural variants in the European mouflon on Sardinia. These sheep are the feral remnants of the first domesticated sheep after they were introduced by humans thousands of years ago. As these sheep experienced two contrasting selective regimes, they are an ideal system to study the genomic imprints of domestication and feralization. First, we will generate a European mouflon reference assembly. Next, we will create a pangenome graph, a new approach that represents genetic variation as alternative sequences. This will allow us to study structural variants in the European mouflon. Altogether, this project will provide insights into how selective pressures shape the genome.