Joint scRNAseq of B and T cells
Dnr:
NAISS 2023/23-445
Type:
NAISS Small Storage
Principal Investigator:
Benjamin Murrell
Affiliation:
Karolinska Institutet
Start Date:
2023-09-26
End Date:
2024-10-01
Primary Classification:
10605: Immunology (medical to be 30110 and agricultural to be 40302)
Webpage:
Allocation
Abstract
The clonality of B-cell and T-cell responses to complex antigens are unknown. We will use 10X single cell RNAseq, including paired chain BCR and TCR sequencing, to understand how B-cell and T-cell lineages respond to an active challenge by complex proteins.