Comparing transcriptional maturity between transplantation sites in transplantation of stem cell islets of Langerhans

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Dnr:

sens2023600

Type:

NAISS SENS

Principal Investigator:

Joey Lau Börjesson

Affiliation:

Uppsala universitet

Start Date:

2023-09-18

End Date:

2024-10-01

Primary Classification:

30108: Cell and Molecular Biology

Webpage:

https://www.mcb.uu.se/forskning/forskargrupper/joey-lau-borjesson/

Allocation

Castor /proj/nobackup at UPPMAX: 1800 GiB
Cygnus /proj/nobackup at UPPMAX: 1800 GiB
Cygnus /proj at UPPMAX: 180 GiB
Castor /proj at UPPMAX: 180 GiB
Bianca at UPPMAX: 5 x 1000 core-h/month

Abstract

Stem cell-derived pancreatic islets (SC-islets) transplantation is a possible future treatment in type 1 diabetes. We compare the transciptional maturity between five different transplant sites with human donor islets and untransplanted SC-islets. RNA-seq was performed on extracted grafts. Sites will be compared using DEGs, heatmaps of maturity and stress genes and PCA.