Helicobacter pylori has a population structure that greatly resembles the one of it's human host. Therefore, H. pylori genomics can be used as a proxy for human genomics to study human migration. H. pylori is also the main risk factor for developing gastric cancer, a disease with very varying incidence in different parts of the world. We aim to assemble an unprecedented , world wide dataset of H. pylori genomes, both from public databases and from in-house sequencing efforts and study both population structure and genetic epistasis of virulence traits that can be linked to cancer risk.