Chromatin organization after mechanical stress
Dnr:
NAISS 2023/23-337
Type:
NAISS Small Storage
Principal Investigator:
Elena Faustini
Affiliation:
Linköpings universitet
Start Date:
2023-06-09
End Date:
2024-07-01
Primary Classification:
30401: Medical Biotechnology (focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Webpage:
Allocation
Abstract
The project focuses on understanding the effect of external mechanical forces on the nucleus, with a particular interest in the chromatin structure. To this end, we use ATAC-seq to determine any change in the chromatin organization (condensation/decondensation) after exposure of Mouse embryonic fibroblasts (MEFs) to shear stress.