Modelling network topology and activity in healthy and pathological striatum
Dnr:
NAISS 2023/5-231
Type:
NAISS Medium Compute
Principal Investigator:
Johannes Hjorth
Affiliation:
Kungliga Tekniska högskolan
Start Date:
2023-06-01
End Date:
2024-06-01
Primary Classification:
10203: Bioinformatics (Computational Biology) (applications to be 10610)
Secondary Classification:
10610: Bioinformatics and Systems Biology (methods development to be 10203)
Webpage:
Allocation
Abstract
During Parkinson disease the striatal projection neurons in the striatum degenerate. These changes in morphology lead to changes in connectivity, and network behaviour. Using detailed electrophysiological models with reconstructed morphologies we investigate the propagation of the disease in the computer model. This is collaborative work with CST EECS KTH, KTH Math department and Neuroscience department at KI, and is also part of the new dBrains initiative.