Human cono-ventricular progenitors during cardiogenesis and congenital heart disease

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Dnr:

NAISS 2023/23-246

Type:

NAISS Small Storage

Principal Investigator:

Makoto Sahara

Affiliation:

Karolinska Institutet

Start Date:

2023-06-01

End Date:

2024-06-01

Primary Classification:

30401: Medical Biotechnology (focus on Cell Biology (incl. Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)

Webpage:

Allocation

Crex 1 at UPPMAX: 4000 GiB

Abstract

Using human ES cell-derived single and bulk RNA-seq and human/NHP/murine embryonic heart-derived single cardiac cell RNA-seq and ATAC-seq, my team aims to decipher mammalian cardiogenesis, the pathogenesis of congenital heart disease and heart regeneration by establishing the developmental heart cellular and its molecular atlases, and to further develop novel therapeutic strategies for heart disease.