Integrative pQTL discovery and tumor mutation burden analysis in UCAN
Dnr:
sens2022015
Type:
SNIC SENS
Principal Investigator:
Tobias Sjöblom
Affiliation:
Uppsala universitet
Start Date:
2022-09-26
End Date:
2024-10-01
Primary Classification:
30107: Medical Genetics
Allocation
- Castor /proj at UPPMAX: 18000 GiB
- Cygnus /proj at UPPMAX: 18000 GiB
- Castor /proj/nobackup at UPPMAX: 3000 GiB
- Cygnus /proj/nobackup at UPPMAX: 3000 GiB
- Bianca at UPPMAX: 100 x 1000 core-h/month
Abstract
The aim of this project is to identify colorectal cancer specific-pQTLs and relate the results to the expressed tumor mutation burden in colorectal cancer patients using the integration of whole-genome sequencing, somatic mutations, RNA-seq and Olink proteome profiling from U-CAN study in Uppsala University. Several computationally intensive analyses will be conducted, including the whole-genome sequencing analysis, RNA-seq analysis, GWAS, colocalization analysis and Mendelian randomization.