,he scope of this study is to elucidate the long-term consequences for parents of children diagnosed with type 1 diabetes (T1D), a chronic autoimmune disease characterized by severe insulin deficiency. Parents ofto children with T1D shoulder the vain responsibility for administrating appropriate doses of insulin several times a day, and must also closely monitor the childrens' blood glucose levels, dietary intake, and physical activity level. Previous small cross-sectional studies have indicated that parents if children with T1DM are at an increased risk of developing stress-related symptoms, however, no large longitudinal study has examined overall cardiovascular and psychiatric health and socioeconomic consequences for parents caring for a child with T1DM. We will conduct a longitudinal population-based cohort study in Sweden, in which we will include the parents of all children (<18 years) born after 1987 diagnosed with T1DM before the age of 18 (app. 52000 parents). We will extract and link information from several different national population and health registers as well as from Swediabkids, a Swedish national quality register for diabetes in children. We will investigate if risk of cardiovascular and psychiatric disease is influenced by the children's T1DM diagnoses, in the first years after diagnoses as well as over time. We will also investigate the socioeconomic consequences for the parents. We will employ population controls, as well as a parental sibling design to address unmeasured familial confounding. We will assess time-updated information on possible effect modifiers including the child's age at diagnosis, glycaemic control, levels of biomarkers, number of hospital admissions, child and parental co-morbidity, and familial circumstances. The findings from this study may enable targeted health intervention efforts aimed at parents of children with T1DM, and also influence social policies regarding the care of children with T1DM.